GHS & Compliance System
Comprehensive regulatory compliance and chemical safety management system
Total Regulations
25
Unread Alerts
8
Critical Issues
2
Compliance Rate
94%
IFRA Amendment 53 - Complete Prohibition of Lilial Effective March 2025
IFRA has released Amendment 53 which includes a complete prohibition of Lilial (Butylphenyl Methylpropional, CAS 80-54-6) in all fragrance applications effective March 1, 2025. This follows ECHA's classification as Reproductive Toxicity Category 1B. All formulations containing Lilial must be reformulated and relabeled. This affects approximately 15% of fine fragrances and 8% of functional fragrances globally.
EU Commission Proposes Expansion of Allergen Declaration List to 29 Substances
European Commission has published a proposal to add 3 new substances to the mandatory allergen declaration list: Atranol (CAS 526-37-4), Chloroatranol (CAS 57074-21-2), and Methyl heptine carbonate (CAS 111-12-6). Additionally, considering potential future additions: Acetyl cedrene, Allyl phenoxyacetate, and others. Public consultation closes December 15, 2024. Expected implementation: Q2 2025 with 18-month transition period.
Thailand Cosmetic Product Re-notification Due November 30, 2024
Annual re-notification required for cosmetic products originally notified in 2021 under Thailand's Cosmetic Control Act. Approximately 247 product registrations in portfolio due for renewal. Late submissions subject to penalties: 5,000-50,000 THB per product. Expired notifications result in products being illegal for sale until re-notified. Processing time: 15-30 days after submission.
Registration, Evaluation, Authorisation and Restriction of Chemicals (EC 1907/2006)
All chemical substances manufactured or imported into the EU in quantities of 1 tonne or more per year must be registered with ECHA. Includes comprehensive safety assessments, substance identification, hazard classification, and safe use guidance. Tonnage bands determine data requirements: 1-10t, 10-100t, 100-1000t, and >1000t annually.
European Chemicals Agency (ECHA) • Effective: 6/1/2007
EC 1223/2009 - Fragrance Allergen Declaration Requirements
26 fragrance allergens must be declared on cosmetic product labels if present above 0.001% (10 ppm) in leave-on products or 0.01% (100 ppm) in rinse-off products. Includes: Amyl cinnamal, Amylcinnamyl alcohol, Anisyl alcohol, Benzyl alcohol, Benzyl benzoate, Benzyl cinnamate, Benzyl salicylate, Cinnamyl alcohol, Cinnamal, Citral, Citronellol, Coumarin, Eugenol, Farnesol, Geraniol, Hexyl cinnamal, Hydroxycitronellal, Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral), Isoeugenol, Lilial, d-Limonene, Linalool, Methyl 2-octynoate, g-Methylionone, Oakmoss extract, Treemoss extract.
European Commission • Effective: 7/11/2013
21 CFR Part 172 & 21 CFR Part 182 - Food Flavoring Substances
Regulation of substances that may be safely used in food as flavoring agents. Includes GRAS (Generally Recognized As Safe) substances listed in 21 CFR Part 182 and approved food additives in 21 CFR Part 172. FEMA GRAS numbers provide industry consensus on safety. Maximum usage levels vary by food category. Electronic GRAS notification process required for new substances since 1997.
Food and Drug Administration (FDA) • Effective: 9/6/1958
IFRA Amendment 53 - Updated Restricted and Prohibited Substances
Latest amendment includes complete prohibition of Lilial (Butylphenyl Methylpropional) effective March 1, 2025, due to reproductive toxicity concerns. Updated restrictions on 180+ fragrance materials based on RIFM safety assessments. Applies to 12 product categories with different restriction levels. Includes specifications for purity, limits on impurities, and prohibited ingredients. Mandatory for IFRA members and widely adopted globally.
IFRA (International Fragrance Association) • Effective: 3/1/2025
Cosmetic Control Act B.E. 2558 (2015) - Notification Requirements
All cosmetic products must be notified to Thai FDA before importation, manufacturing, or sale in Thailand. Notification valid for 3 years, renewable. Requires: product formula disclosure, safety assessment, manufacturing site license, quality control data, labeling compliance. Special requirements for products containing restricted substances or making therapeutic claims. Separate notifications required for each formulation variant.
Thai FDA (Food and Drug Administration) • Effective: 3/17/2015